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Stability of cefepime in icodextrin peritoneal dialysis solution
Rowland J Elwell1, Lucio R Volino, Reginald F Frye
1Department of Pharmacy Practice, Albany College of Pharmacy, 106 New Scotland Ave., Albany, NY 12208-3492, USA. elwellr@acp.edu
The Annals of Pharmacotherapy
|October 21, 2004
Summary
Cefepime and icodextrin peritoneal dialysis (PD) solutions are stable for up to 7 days when refrigerated. Room temperature storage is suitable for 48 hours, while body temperature is best for 4 hours, allowing pre-warming before administration.
Area of Science:
- Pharmaceutical Sciences
- Nephrology
- Clinical Pharmacy
Background:
- Icodextrin is an osmotic agent in peritoneal dialysis (PD) solutions.
- Cefepime is a potential antibiotic for PD-related peritonitis.
- Cefepime stability in icodextrin PD solutions requires investigation.
Purpose of the Study:
- To assess the chemical stability of cefepime in icodextrin PD solution.
- To evaluate stability over a 7-day period under various storage conditions.
Main Methods:
- Cefepime HCl was added to icodextrin 7.5% PD solution.
- Samples were stored at 4°C, 20°C, and 37°C.
- Cefepime concentration was measured using liquid chromatography-tandem mass spectrometry over 7 days.
Main Results:
- Refrigerated solutions retained >95% cefepime for 7 days.
- Room temperature storage maintained >92% cefepime for 48 hours.
- Body temperature storage maintained >92% cefepime for 4 hours.
Conclusions:
- Pre-mixed cefepime-icodextrin PD solutions are stable for 48 hours at room temperature.
- Refrigeration ensures stability for up to 7 days.
- Body temperature stability for 4 hours supports pre-warming practices.