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Adjunctive granulocyte colony-stimulating factor therapy for diabetic foot infections
Kelly S Reed1, Manjunath P Pai
1Providence St. Vincent Medical Center, Portland, OR, USA.
Objective:
To evaluate the role of granulocyte colony-stimulating factor (G-CSF) as adjunctive therapy for the treatment of diabetic foot infections in non-neutropenic patients.
Data Sources:
Clinical literature was accessed through MEDLINE (1965-April 2004). Key search terms included G-CSF, infection, and diabetes. In addition, relevant references from primary and secondary article bibliographies were extracted.
Data Synthesis:
Three clinical trials evaluating G-CSF for diabetic foot infections were identified. These data demonstrated positive effects of G-CSF on improvement of foot infections and risk of amputations.
Conclusions:
Controlled trials are necessary to validate the role of adjunctive G-CSF at reducing amputations in patients with diabetic foot infections.
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