Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A second-generation genomic screen for multiple sclerosis.

S J Kenealy1, M-C Babron, Y Bradford

  • 1Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37232-0700, USA.

American Journal of Human Genetics
|October 21, 2004
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Determinants of the experience of patients living with multiple sclerosis in terms of care pathway quality: An original French study.

Revue neurologique·2025
Same author

Dyadic coping strategies and quality of care experience: An original study of patients living with multiple sclerosis and their caregivers.

Revue neurologique·2023
Same author

Impact of methodological choices in comparative effectiveness studies: application in natalizumab versus fingolimod comparison among patients with multiple sclerosis.

BMC medical research methodology·2022
Same author

Developing tools to evaluate quality of care management for patients living with multiple sclerosis: An original French initiative.

Revue neurologique·2022
Same author

Ten-year follow-up after mitoxantrone induction for early highly active relapsing-remitting multiple sclerosis: An observational study of 100 consecutive patients.

Revue neurologique·2022
Same author

Evaluation of the quality of the care pathway for patients with multiple sclerosis in France: Results of an original study of a cohort of 700 patients.

Revue neurologique·2021
Same journal

Bi-allelic missense variants in human GPN2 result in Perrault syndrome.

American journal of human genetics·2026
Same journal

Integrative analysis of gastric tissue transcriptomes and gastric cancer GWAS implicates candidate susceptibility genes.

American journal of human genetics·2026
Same journal

A transparent and generalizable deep-learning framework for genomic ancestry prediction.

American journal of human genetics·2026
Same journal

Data-driven RNA phenotyping captures genetically regulated dimensions of the transcriptome.

American journal of human genetics·2026
Same journal

Linkage disequilibrium and allelic heterogeneity explain variation in coronary artery disease risk at 9p21 across populations and reduced effect in Africans.

American journal of human genetics·2026
Same journal

Genome-wide association study and predictors of neonatal blood cell traits in Hispanic newborns.

American journal of human genetics·2026
See all related articles
This summary is machine-generated.

This study identified new chromosomal regions linked to multiple sclerosis (MS) susceptibility genes. These findings expand the search beyond the major histocompatibility complex for understanding MS genetic underpinnings.

Area of Science:

  • Neuroimmunology
  • Neurogenetics
  • Human Genetics

Background:

  • Multiple sclerosis (MS) is a complex neuroimmunological and neurodegenerative disease with a known polygenic inheritance pattern.
  • The major histocompatibility complex (MHC) is the only consistently identified genetic region associated with MS susceptibility.
  • Identifying additional genetic loci is crucial for a comprehensive understanding of MS etiology.

Purpose of the Study:

  • To conduct the largest genomic screen for multiple sclerosis (MS) to date.
  • To identify novel chromosomal regions harboring MS susceptibility genes.
  • To investigate potential genetic linkages in U.S. and French multiplex families.

Main Methods:

  • Utilized a genome-wide scan with 390 microsatellite markers.

Related Experiment Videos

  • Analyzed data from 245 U.S. and French multiplex families (456 affected relative pairs).
  • Applied heterogeneity LOD (HLOD) and Z score thresholds (>2.0) for linkage analysis, with further stratification by country and HLA-DR2 status.

    • Main Results:

    • Identified four regions meeting primary criteria: 1q, 6p, 9q, and 16p.
    • Two additional regions (3q, 5q) met the Z score criterion.
    • Sub-analyses revealed suggestive linkage in 18p (U.S.), 1p and 22q (French), and several regions stratified by HLA-DR2 status (2q, 6q, 13q, 16q).

    Conclusions:

    • The study successfully identified several novel chromosomal regions potentially harboring MS susceptibility genes.
    • These findings provide a foundation for future research to pinpoint specific genes contributing to MS.
    • The results underscore the polygenic nature of MS and highlight the importance of continued genomic investigation.