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Multiple primary soft tissue sarcomas.
Stephen R Grobmyer1, Neal Luther, Cristina R Antonescu
1Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Cancer
|October 21, 2004
Summary
Patients with a history of soft tissue sarcoma (STS) face an increased risk of developing a second primary STS. This study found a significantly higher incidence of secondary STS in these patients compared to the general population.
Area of Science:
- Oncology
- Surgical Pathology
Background:
- Multiple primary soft tissue sarcomas (STS) of differing histopathology are rarely documented.
- Previous reports primarily consist of isolated case studies.
Purpose of the Study:
- To investigate the incidence and characteristics of multiple primary STS.
- To determine if patients with a history of STS have an elevated risk for developing a second primary STS.
Main Methods:
- Retrospective review of patient records from a tertiary cancer center (1982-2003).
- Identification of patients diagnosed with multiple primary STS.
Main Results:
- Nine patients with multiple primary STS were identified, representing 0.2% of all STS cases.
- The majority (7/9) developed metachronous (sequential) second primary STS.
- The incidence of secondary STS in patients with prior STS was significantly higher (4.0 per 10,000 person-years) than primary STS in the general population (3.2 per 100,000 person-years).
Conclusions:
- Patients with a history of STS exhibit an increased risk for developing a second primary STS.
- While uncommon, this increased risk warrants consideration in patient monitoring and management.