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Related Experiment Videos

Exercise for people with peripheral neuropathy.

C M White1, J Pritchard, L Turner-Stokes

  • 1Physiotherapy Division, GKT School of Biomedical Sciences, Kings College London, Shepherds House, Guy's Campus, London Bridge, London, UK, SE1 1UL. claire.white@kcl.ac.uk

The Cochrane Database of Systematic Reviews
|October 21, 2004
PubMed
Summary

Exercise therapy shows limited evidence for improving functional ability in peripheral neuropathy. However, progressive resisted exercise may offer moderate benefits for muscle strength in affected individuals.

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Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Clinical Trials

Background:

  • Peripheral neuropathies encompass diverse diseases impacting peripheral nerves, leading to sensory alterations, pain, weakness, and fatigue.
  • These conditions can result in secondary psychological and social functional impairments.
  • Exercise therapy is a recognized component of management, particularly for strength and stamina development in chronic or recovering neuropathies.

Purpose of the Study:

  • To evaluate the impact of exercise therapy on functional ability in peripheral neuropathy patients.
  • To assess secondary outcomes including muscle strength, endurance, overall well-being, and adverse events.

Main Methods:

  • Searched multiple electronic databases (Cochrane, MEDLINE, EMBASE, CINAHL, LILACS) up to June 2004.

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  • Included randomized or quasi-randomized controlled trials comparing exercise therapy with no exercise or alternative treatments for peripheral neuropathy.
  • Two reviewers independently assessed study eligibility, quality, and extracted data.

    • Main Results:

    • Only one trial fully met inclusion criteria; two additional trials with shorter follow-up were included.
    • Methodological quality was generally poor, precluding data pooling due to heterogeneity.
    • No significant effect of strengthening and endurance exercise on functional ability was found, though some evidence suggested moderate improvements in muscle strength.

    Conclusions:

    • Insufficient evidence exists to definitively assess exercise's effect on functional ability in peripheral neuropathy.
    • Preliminary findings suggest progressive resisted exercise may enhance muscle strength in affected individuals.