Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Amphetamines for schizophrenia.

S Nolte1, D Wong, G Lachford

  • 1Department of Psychiatry & Behavioural Sciences, 15 Hyde Terrace, Leeds, LS2 9JT, West Yorkshire, UK. klienus@hotmail.com

The Cochrane Database of Systematic Reviews
|October 21, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Purdue Pegboard test for surveillance of vibration-exposed workers.

Occupational medicine (Oxford, England)·2025
Same author

Anti-HBs Immune Complex Levels: A Novel Marker of Hepatitis Flare Following Nucleos(t)ide Analog Withdrawal in HBeAg-negative Chronic Hepatitis B.

The Journal of infectious diseases·2025
Same author

Factors associated with chronic depressive symptoms across adolescence and young adulthood: a UK birth cohort study.

Epidemiology and psychiatric sciences·2024
Same author

Effects of transcranial direct current stimulation and transcranial random noise stimulation on working memory and task-related EEG in major depressive disorder.

Brain and cognition·2023
Same author

Pancreatic Adenocarcinoma: Real World Evidence of Care Delivery in AccessHope Data.

Journal of personalized medicine·2023
Same author

Cochlear implantation in advanced otosclerosis: utility of pre-operative radiological assessment in predicting intra-operative difficulty and final electrode position.

The Journal of laryngology and otology·2023
Same journal

Interventions to prevent or cease electronic cigarette use in children and adolescents.

The Cochrane database of systematic reviews·2026
Same journal

Drugs to improve anaemia, quality of life, and physical function in people with myelodysplastic syndromes (MDS).

The Cochrane database of systematic reviews·2026
Same journal

Interventions for smoking cessation in inpatient psychiatry settings.

The Cochrane database of systematic reviews·2026
Same journal

Mechanical thromboprophylaxis for preventing intradialytic hypotension in people undergoing maintenance haemodialysis.

The Cochrane database of systematic reviews·2026
Same journal

Prognostic models for predicting intensive care unit admission or mortality in critically ill adults not yet been admitted to the intensive care unit.

The Cochrane database of systematic reviews·2026
Same journal

Views and experiences of weight management for people living with mobility‑limiting conditions, intellectual disabilities or severe mental illness: a qualitative evidence synthesis.

The Cochrane database of systematic reviews·2026
See all related articles

Amphetamines may reduce negative symptoms in schizophrenia patients but show no effect on positive symptoms. Further research is needed to understand why individuals with schizophrenia use these harmful stimulants.

Area of Science:

  • Psychiatry
  • Neuroscience
  • Clinical Psychology

Background:

  • An estimated 10% to 65% of individuals with schizophrenia use illicit drugs, including amphetamines.
  • This population experiences higher rates of hospitalization, homelessness, unemployment, and suicide compared to those without drug abuse.
  • Understanding the impact of amphetamine use in schizophrenia is crucial due to its prevalence and associated negative outcomes.

Purpose of the Study:

  • To systematically evaluate the effects of amphetamines in individuals with schizophrenia.
  • Assess impacts on clinically meaningful outcomes, cognitive functioning, and physiological measures.
  • Synthesize findings from randomized controlled trials (RCTs) to inform clinical practice and future research.

Main Methods:

  • Searched the Cochrane Schizophrenia Group's Register for relevant studies.

Related Experiment Videos

  • Included all randomized controlled trials comparing amphetamines to placebo in schizophrenia patients.
  • Data extraction and analysis were performed independently, calculating risk ratios, confidence intervals, and weighted mean differences.

    • Main Results:

    • Four short studies with 83 participants were included; data quality was limited.
    • Amphetamines showed a reduction in negative symptoms (WMD -3, CI -5.02 to -0.98) but no significant effect on positive symptoms.
    • Significant alterations in brain metabolism were observed: increased in cerebellum and striatum, decreased in the dorsolateral prefrontal cortex.

    Conclusions:

    • Formal evaluation of amphetamines in schizophrenia via randomized studies is rare, suggesting potential unpublished data.
    • Further research is necessary to elucidate the reasons behind persistent amphetamine use in individuals with schizophrenia.
    • Clarifying these motivations could aid in developing targeted interventions and support strategies.