Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Laminopathies.

Jos L V Broers1, Chris J Hutchison, Frans C S Ramaekers

  • 1Department of Molecular Cell Biology, Research Institutes CARIM, GROW, and EURON, University of Maastricht, The Netherlands.

The Journal of Pathology
|October 21, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Variable A-type lamin expression in Merkel cell carcinoma cell lines and its association with nuclear integrity.

Scientific reports·2026
Same author

Increased anti-apoptotic (Bcl-2+) and decreased proliferative (Ki-67+) cell fractions during the different maturation stages of bone marrow cell populations in MDS and AML: The potential diagnostic impact of the Bcl-2:Ki-67 ratio.

Cytometry. Part B, Clinical cytometry·2025
Same author

MDS and AML show elevated fractions of CD34-positive blast cell populations with a high anti-apoptotic versus proliferation ratio.

Leukemia research·2024
Same author

Inhibition of cytosine 5-hydroxymethylation during progression of cancer precursor lesions in the uterine cervix.

PloS one·2024
Same author

Impact of the gating strategy for Ki-67 and Bcl-2 on the determination of proliferation and anti-apoptosis data by flow cytometry in non-malignant bone marrow aspirates and aspirates from patients with myeloid malignancies.

Data in brief·2023
Same author

Impact of antigen retrieval protocols on the immunohistochemical detection of epigenetic DNA modifications.

Histochemistry and cell biology·2023

Nuclear lamins are key structural proteins influencing nuclear function and gene regulation. Their dual roles as structural components and transcription regulators are central to understanding laminopathies, genetic diseases caused by lamin mutations.

Area of Science:

  • Cell Biology
  • Structural Biology
  • Genetics

Background:

  • Nuclear lamins form a fibrous network supporting the inner nuclear membrane and embedding nuclear pore complexes.
  • Lamins are evolutionary precursors to cytoplasmic intermediate filament proteins, impacting nuclear structure and function.
  • Lamins possess dynamic properties and dual roles as structural elements and transcription regulators.

Purpose of the Study:

  • To explore the dual identities of nuclear lamins as structural components and transcription regulators.
  • To investigate the underlying mechanisms of laminopathies, genetic disorders linked to lamin mutations.

Main Methods:

  • Analysis of the structural organization of nuclear lamins within the nuclear envelope.
  • Investigation of the functional roles of lamins in nuclear structure and gene transcription.

Related Experiment Videos

  • Review of genetic studies on laminopathies caused by mutations in lamins or associated proteins.

    • Main Results:

    • Nuclear lamins establish a peripheral nucleoskeletal network and can form intranuclear structures.
    • Lamins significantly influence nuclear architecture and are involved in regulating gene transcription.
    • The precise role of lamin identities in the pathogenesis of laminopathies remains under active investigation.

    Conclusions:

    • Nuclear lamins are essential for nuclear structure and function, exhibiting dual roles.
    • Understanding the balance between lamin structural and regulatory functions is crucial for deciphering laminopathies.
    • Further research is needed to resolve the debate on which lamin identity is primarily implicated in laminopathies.