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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

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[Application of immunomodulators for correction of changes in the immune system in conditions of experimental

H A Zamotaieva, D S Sydorenko, N M Stepura

    Klinichna Khirurhiia
    |October 22, 2004
    PubMed

    Changes of the immune system state were investigated in mice after performance of thyroidectomy under the influence of hormonal therapy using thyroxin and immunotropic preparations thymogen and polyoxydonium. In hypothyrosis there was observed the trustworthy lowering of the thymus endocrine function, interleukine-2 activity, cytotoxic activity in the physiological cell-killers, the leukocytes proliferating ability and increase of the blood content of circulating immune complexes as well. The restorational therapy conduction using thyroxin, injections of thymogen or polyoxydonium removed the above mentioned changes only in part. The immunomodulators application, under condition of the hypothyrosis compensation occurrence, have had promoted the essential raising of their therapeutic action and secured the immune state restoration after thyroidectomy performance.

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