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Updated: Aug 21, 2026
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Published on: May 26, 2021
Effect of the flavonol quercetin on membrane conductances in rat colonic crypt cells
Rainer Cermak1, Siegfried Wolffram, Gisela Kuhn
1Institute of Animal Nutrition and Physiology, Christian-Albrechts-University of Kiel, Olshausenstr. 40, D-24098 Kiel, Germany. cermak@aninut.uni-kiel.de
Abstract:
The plant polyphenol quercetin was shown to induce Cl- secretion in rat colon. This study was performed to investigate the alterations of membrane conductances in isolated epithelial cells induced by quercetin. Whole-cell patch-clamp recordings were performed in isolated crypts from rat distal colon. In cells of the crypt basis, quercetin significantly hyperpolarized the membrane potential at concentrations > or =3 microM and increased the K+ conductance without visibly altering the Cl- conductance. Thus, quercetin induces Cl- secretion merely by activation of K+ channels in the colon epithelium.
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