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Updated: Aug 21, 2026

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
Published on: May 24, 2021
[Normal cardiac diameters in cine-MRI of the heart]
1Zentrales Institut für Radiologie, Landeskrankenhaus Feldkirch, Feldkirch, Osterreich. klaus.hergan@lkhf.at
Insights
This study measured normal cardiac cavity diameters using cine MRI, establishing reference values for assessing heart size and hypertrophy. These findings simplify the detection of abnormal cardiac dimensions in clinical practice.
Area of Science:
- Cardiovascular Imaging
- Radiology
- Cardiac Anatomy
Background:
- Accurate measurement of cardiac dimensions is crucial for diagnosing various cardiovascular conditions.
- Standardized reference values are essential for interpreting cardiac imaging findings.
Purpose of the Study:
- To establish normal diameter ranges for cardiac cavities using cine MRI.
- To provide reference values for assessing ventricular dilatation and hypertrophy.
Main Methods:
- Fifty-six healthy volunteers (27 male, 29 female) underwent cine MRI using SSFP sequences.
- Standard echocardiographic views (short axis, 4-chamber, 2-chamber) were utilized.
- Cardiac cavity diameters and septal wall thickness were measured via a standardized protocol.
Main Results:
- Normal diastolic/systolic diameters for left and right ventricles were determined, with male volunteers generally showing larger dimensions than females.
- Diastolic and systolic septal wall thickness measurements were established, with males exhibiting greater thickness.
- Correlation was observed between septal thickness measurements in different views; longitudinal diameters varied by view and cardiac cycle phase.
Conclusions:
- Cine MRI allows for quick and easy measurement of cardiac cavity diameters.
- Published normal values facilitate the assessment of abnormal heart sizes and hypertrophy.
Purpose:
To measure the normal diameters of cardiac cavities in standard cardiac views using cine MRI.
Materials And Methods:
Fifty-six volunteers were examined (27 male, 29 female) on a 1.5 T MR unit with ECG-triggered single shot free precision (SSFP) cine MR sequences and parallel image acquisition. Standardized echocardiographic planes were used to depict the heart of all volunteers (short axis, 4-chamber view, left and right 2-chamber views). The different diameters of the cardiac cavities were measured using a fixed protocol.
Results:
For the estimation of ventricular dilatation, the important female/male cross diameters of the left ventricle are 45.2 +/- 3.4/51.6 +/- 4.6 mm diastolic and 30.5 +/- 3.5/33.8 +/- 3.6 mm systolic, and of the right ventricle 30.7 +/- 3.8/37.1 +/- 5.9 mm diastolic and 22.3 +/- 3.8/28.1 +/- 4.4 mm systolic. For the determination of a left ventricular hypertrophy, relevant septal wall thickness measured in the short axis of the left ventricle of female/male volunteers are 8.0 +/- 1.0/9.9 +/- 1.2 mm diastolic and 10.9 +/- 1.4/13.6 +/- 1.9 mm systolic. The measured normal values of male volunteers were generally higher than those of female volunteers. The thickness of the ventricular septum correlated well when measured in the short axis and 4-chamber view. When measured in the 4-chamber view, the longitudinal diameter of the ventricles had a higher value in diastole and a lower value in systole, compared to the 2-chamber views of the right and left cardiac cavities. The atrial longitudinal diameters were higher in the 4-chamber view compared to the 2-chamber views, without any difference in systole or diastole.
Conclusion:
Diameters of cardiac cavities are easily and quickly measured. Using the tables with the normal values published here, it is simple to estimate an abnormal size of the heart.
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