Related Experiment Video
Updated: Aug 21, 2026

Ferric Chloride-induced Murine Thrombosis Models
Published on: September 5, 2016
Inherited thrombocytopenias: molecular mechanisms
Carlo L Balduini1, Anna Savoia
1IRCCS Policlinico San Matteo, University of Pavia, Italy. c.balduini@smatteo.pv.it
Abstract:
Each megakaryocyte forms 10(3) platelets and 10(11) platelets are replenished daily. The unique and amazing mechanisms that allow megakaryocytes to become giant and polyploid and to release such a large number of platelets are still poorly understood. The study of inherited thrombocytopenias offers the possibility to gain new information on these processes because several different forms, deriving from defective megakaryocytic commitment, differentiation, maturation, or platelet formation, have been identified. Moreover, in the presence of some genetic defects, megakaryocytes produce platelets with a shortened life span. In this review, we summarize what we have learned about inherited thrombocytopenias in the last few years.
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