Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatic tissue engineering for adjunct and temporary liver support: critical technologies.

Christina Chan1, François Berthiaume, Bharath D Nath

  • 1Center for Engineering in Medicine/Surgical Services, Massachusetts General Hospital, Harvard Medical School, and the Shriners Hospitals for Children, Boston, MA 02114, USA.

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
|October 22, 2004
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tangential flow filtration for isolating exomeres and other nanoscale extracellular particles.

Nanoscale·2026
Same author

Generation of Cellular Biofactories for the Scalable Production of Surface-Engineered Extracellular Vesicles via CRISPR Genome Editing.

ACS biomaterials science & engineering·2026
Same author

NRSF regulation of OPRM1 through histone acetylation.

Clinical epigenetics·2026
Same author

Coacervates Made of Elastin-Like Polypeptides Fused with Melanocyte-Stimulating Hormone and Monocyte Chemoattractant Protein Enhance Skin Wound Healing in Spinal Cord-Injured Mice.

Advanced healthcare materials·2026
Same author

Endoplasmic reticulum stress induced autophagy alters cellular processing of cationic lipid delivered siRNAs.

Drug delivery and translational research·2026
Same author

Using electronic health records to assess the relationship between colonization pressure and nosocomial pathogen acquisition.

Nature communications·2026

Tissue engineering offers promising alternatives to liver transplantation for end-stage liver disease. Current bioartificial liver devices show potential but require further development for reliable clinical use.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Hepatology

Background:

  • Orthotopic liver transplantation faces challenges including donor organ shortage, high costs, and procedural complexity.
  • End-stage liver disease necessitates innovative treatments that are less invasive and more accessible.
  • Hepatic tissue engineering presents a viable alternative, exploring both internal and external liver support systems.

Purpose of the Study:

  • To review the progress and engineering challenges in developing tissue-engineered liver support systems.
  • To explore implantable and extracorporeal devices for adjunct or temporary liver assistance.
  • To identify key areas for future research to enable routine clinical application.

Main Methods:

  • Review of preclinical and clinical studies on hepatic tissue engineering.

Related Experiment Videos

  • Engineering perspective analysis of current bioartificial liver assist devices.
  • Assessment of technological hurdles in developing next-generation liver support.

    • Main Results:

    • Numerous tissue-engineered liver support systems have demonstrated proof of principle.
    • Current systems, while promising, lack the reliable effectiveness for widespread clinical adoption.
    • Significant engineering advancements are needed to overcome existing limitations.

    Conclusions:

    • Hepatic tissue engineering holds substantial promise for managing end-stage liver disease.
    • Further engineering innovation is crucial to translate current research into reliable clinical solutions.
    • The development of advanced implantable and extracorporeal liver assist devices is essential for future liver support.