Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Comments on the Jayjock et al. paper.

K K Rozman1

  • 1Department of Pharmacology, Toxicology and Therapeutics, the University of Kansas, 66160-7417, USA. krozman@kumc.edu

Human & Experimental Toxicology
|October 23, 2004
PubMed
Summary

Hormesis, an evolution-based phenomenon, challenges current risk assessment methods. This study examines its practical application from a toxicologist's viewpoint, considering dose-response variability.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on weight gain and hepatic ethoxyresorufin-o-deethylase (EROD) induction vary with ovarian hormonal status in the immature gonadotropin-primed rat model.

Reproductive toxicology (Elmsford, N.Y.)·2001
Same author

Impaired ovulation by 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) in immature rats treated with equine chorionic gonadotropin.

Reproductive toxicology (Elmsford, N.Y.)·2001
Same author

A review of mechanisms controlling ovulation with implications for the anovulatory effects of polychlorinated dibenzo-p-dioxins in rodents.

Toxicology·2001
Same author

Paracelsus, Haber and Arndt.

Toxicology·2001
Same author

The role of time as a quantifiable variable of toxicity and the experimental conditions when Haber's c x t product can be observed: implications for therapeutics.

The Journal of pharmacology and experimental therapeutics·2001
Same author

Kinetics of monochloroacetic acid in adult male rats after intravenous injection of a subtoxic and a toxic dose.

The Journal of pharmacology and experimental therapeutics·2001

Area of Science:

  • Toxicology
  • Biological Sciences
  • Evolutionary Biology

Background:

  • The concept of hormesis, where low doses of a toxin can have beneficial effects, is explored in relation to established risk assessment paradigms.
  • The Jayjock et al. papers offer an industrial hygienist's perspective on hormesis, contributing to the ongoing scientific discourse.

Discussion:

  • This commentary provides a toxicologist's critical evaluation of the practical limitations and feasibility of the suggestions proposed by Jayjock et al.
  • The discussion centers on the inherent complexities of dose-response relationships and time-dependent effects, including their variability and uncertainty.

Key Insights:

  • Hormesis requires a robust, evolution-based framework for its acceptance as a biological phenomenon.
  • Toxicological interpretation of hormesis is constrained by the variability and uncertainty in observed dose- and time-response data.

Outlook:

  • Further research is needed to reconcile the industrial hygienist and toxicologist perspectives on hormesis.
  • Developing standardized methodologies for assessing hormesis is crucial for its integration into risk assessment frameworks.

Related Experiment Videos