Related Experiment Video
Updated: Aug 16, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
Noncardiogenic pulmonary edema in low-dose oral methotrexate therapy
Noriko Iikuni1, Sumiko Iwami, Shogo Kasai
1Department of Internal Medicine, Social Insurance Central General Hospital, Tokyo.
Abstract:
In the past two decades, low-dose methotrexate (MTX) has been widely used in the treatment of rheumatoid arthritis (RA). As adverse effects, various types of pulmonary toxicity have been reported with this therapy. We report a case of MTX-induced noncardiogenic pulmonary edema in a 35-year-old woman. MTX used in high dose for anti-cancer therapy is known to cause non-cardiogenic pulmonary edema. However, there are no previous reports of noncardiogenic pulmonary edema caused by low-dose MTX therapy. This report suggests that patients receiving oral weekly, low-dose MTX may be at risk for the development of noncardiogenic pulmonary edema.
Related Concept Videos
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Therapeutic Drug Monitoring: Affecting Factors
Mitral Stenosis IV: Nursing Management
Cardiomyopathy V: Interprofessional Care
Cardiomyopathy VI: Nursing Management
Pulmonary Edema II: Pathophysiology
