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Updated: Aug 21, 2026

An Invasive Method for the Activation of the Mouse Dentate Gyrus by High-frequency Stimulation
Published on: June 2, 2018
Mechanisms of action of GH
E E Müller1, A E Rigamonti, S G Cella
1Department of Medical Pharmacology, Faculty of Medicine, University of Milan, Milan, Italy. eugenio.muller@unimi.it
Abstract:
The process of growth, which is common to all multicellular organisms, is complex and involves the interaction of a multiplicity of factors; despite this, the GH/IGF function still maintains its preminence, and, in turn, the same is true for all approaches aimed at reducing the consequences of GH/IGF excess. In this review paper, we will deal briefly with some aspects of GH/IGF mechanism of action which are instrumental to the appreciation of a novel class of a "designer" GH antagonist, for use in conditions characterized by excess GH action and elevated serum IGF-I.
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