Related Experiment Video
Updated: Aug 21, 2026

Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
Published on: April 15, 2013
Scabrosin esters and derivatives: chemical derivatization studies and biological evaluation
Christina L L Chai1, John A Elix, Paul B Huleatt
1Centre for the Study of Bioactive Molecules, Department of Chemistry, Australian National University, Canberra ACT 0200, Australia. christina.chai@anu.edu.au
Abstract:
Several derivatives of the natural scabrosin esters were synthesized in order to elucidate the structural features present, which are responsible for the biological activities. The studies demonstrate that full anti-proliferative activities of the scabrosin esters, both the carboskeleton core as well as the ability to form the dithiol and/or the disulfide linkage of the epidithiopiperazine-2,5-dione are required. The presence of the epoxide rings on the scabrosin esters do not contribute to the observed biological activities.
Related Concept Videos
Carboxylic Acid Derivatives: Overview
Alkylation of β-Ketoester Enolates: Acetoacetic Ester Synthesis
Esters to Carboxylic Acids: Saponification
The reaction requires a base in stoichiometric amounts, which participates in the reaction and is not regenerated later. So, the base acts as a...
Alkylation of β-Diester Enolates: Malonic Ester Synthesis
Carboxylic Acids to Esters: Acid-Catalyzed (Fischer) Esterification Mechanism
Reactions of Aldehydes and Ketones: Baeyer–Villiger Oxidation
The carbonyl center is activated by...
