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Published on: March 14, 2017
Parathyroid hormone and calcium behavior in advanced congestive heart failure
T Stefenelli1, R Pacher, W Woloszczuk
1Universitätsklinik für Innere Medizin II, Abteilung für Kardiologie, Wien, Osterreich.
Zeitschrift Fur Kardiologie
|February 1, 1992
Summary
Abnormal parathyroid hormone (PTH) secretion is common in advanced heart failure. PTH release is depressed during exercise stress in these patients, suggesting parathyroid gland dysfunction.
Area of Science:
- Cardiology
- Endocrinology
Background:
- Parathyroid hormone (PTH) regulates calcium and influences myocardial function.
- Abnormal PTH secretion is linked to impaired heart muscle performance.
Purpose of the Study:
- To investigate baseline PTH levels in advanced congestive heart failure.
- To assess PTH and calcium response to exercise stress in heart failure patients.
Main Methods:
- Measured baseline PTH in 27 advanced heart failure patients (LVEF: 17 +/- 9%).
- Conducted symptom-limited exercise stress tests on nine patients, monitoring PTH and blood calcium.
- Analyzed PTH and calcium changes during exercise and recovery.
Main Results:
- 18.5% of patients had elevated baseline PTH; one case of hypoparathyroidism identified.
- In heart failure patients, PTH and blood calcium did not significantly change during exercise stress.
- Patients with lowest ejection fraction showed decreased PTH during maximal stress.
Conclusions:
- Abnormal baseline PTH secretion is prevalent in advanced congestive heart failure.
- PTH release is blunted under stress in severe heart failure, indicating potential parathyroid dysfunction.
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