Related Experiment Video
Updated: Aug 11, 2026

A Quantitative Assay for Insulin-expressing Colony-forming Progenitors
Published on: November 28, 2011
The source(s) for new pancreatic beta cells in adult life
1Research Laboratory for Stereology and Neuroscience, H:S Bispebjerg Hospital, Copenhagen, Denmark. tbock@post12.tele.dk
Abstract:
The natural source for new pancreatic beta cells is an important issue both for understanding the pathogenesis of diabetes, and for possibly curing diabetes by increasing the number of beta cells. Dor et al. investigated beta-cell renewal and regeneration by genetic lineage analysis in mice during physiological growth and after partial pancreatectomy. The data conclusively showed that beta-cell replication was the only source for new beta cells without contributions from stem cells or other non-beta cells. This underlines the capacity for beta-cell self-renewal and casts doubt that other cell types are able to generate new beta cells in the intact pancreas.
More Related Videos
07:44Surgical Injury to the Mouse Pancreas through Ligation of the Pancreatic Duct as a Model for Endocrine and Exocrine Reprogramming and Proliferation
Published on: August 7, 2015
09:31In Vitro Colony Assays for Characterizing Tri-potent Progenitor Cells Isolated from the Adult Murine Pancreas
Published on: June 10, 2016
Related Concept Videos
Insulin Secretory Vesicles
Tissue Renewal without Stem Cells
However, failure of such a system...
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion
Insulin and C-peptide are co-secreted in...