Effect of extracts from Rhodiola rosea and Rhodiola crenulata (Crassulaceae) roots on ATP content in mitochondria of...

Area of Science:

• Pharmacology
• Exercise Physiology
• Biochemistry

Background:

• Rhodiola species are known for adaptogenic properties.
• Investigating the specific effects of Rhodiola rosea and Rhodiola crenulata on physical performance is crucial.
• Understanding the impact on energy metabolism provides insights into their efficacy.

Purpose of the Study:

• To compare the effects of Rhodiola rosea and Rhodiola crenulata root extracts on physical endurance.
• To evaluate the influence of these extracts on ATP content in skeletal muscle mitochondria.
• To determine which Rhodiola species is more effective for enhancing physical working capacity.

Main Methods:

• Oral administration of Rhodiola rosea and Rhodiola crenulata extracts (50 mg/kg) to rats.
• Measurement of the duration of exhaustive swimming to assess physical endurance.
• Analysis of ATP content in skeletal muscle mitochondria.

Main Results:

• Rhodiola rosea extract significantly increased the duration of exhaustive swimming by 24.6% compared to controls and Rhodiola crenulata.
• Rhodiola rosea extract enhanced ATP synthesis and resynthesis in mitochondria.
• The extract stimulated reparative energy processes following strenuous exercise.

Conclusions:

• Rhodiola rosea demonstrates superior efficacy in improving physical working capacity compared to Rhodiola crenulata.
• Rhodiola rosea positively impacts skeletal muscle energy metabolism, particularly ATP production and recovery.
• The findings highlight distinct pharmacological profiles of the two Rhodiola species.