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Updated: Aug 12, 2026

Transcutaneous Assessment of Renal Function in Conscious Rodents
Published on: March 26, 2016
[Gene polymorphisms of renin-angiotensin system in patients with kidney diseases]
Ichiei Narita1, Fumitake Gejyo
1Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences.
Abstract:
Blockade of the renin-angiotensin system (RAS), such as angiotensin-converting enzyme inhibitor and/or angiotensin receptor blocker, has been well appreciated as a renoprotective treatment in proteinuric glomerular diseases. However, not all patients with glomerular diseases respond well to this therapy. Single nucleotide polymorphisms (SNPs) in angiotensin-converting enzyme (ACE) and angiotensinogen may be involved in the inter-individual difference in the responsiveness to the renoprotective efficacy of the RAS blockade. This review focuses on the interface between genomics and therapeutics in the renin-angiotensin system in IgA nephropathy, the most prevalent form of primary glomerulonephritis and one of the major causes of end-stage renal disease in the world.
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