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A quantitative method to evaluate corrosion products in tissues.

R L Cabrini1, D G Olmedo, M B Guglielmotti

  • 1Department of Oral Pathology, Faculty of Dentistry, University of Buenos Aires, Argentina.

Acta Odontologica Latinoamericana : AOL
|October 27, 2004
PubMed
Summary

This study introduces a new method for quantifying corrosion product deposits in tissues from metal implants. This technique aids in assessing tissue response to implant corrosion, crucial for dental and orthopedic applications.

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Area of Science:

  • Biomaterials Science
  • Histopathology
  • Materials Science

Background:

  • Metal implants (dental, orthopedic) can corrode, leading to tissue deposition of corrosion products.
  • Previous studies confirmed local and systemic deposition of these products in organs like the liver, spleen, and lung.
  • Accurate quantitative assessment methods are needed to understand tissue response to implant corrosion.

Purpose of the Study:

  • To propose a novel method for the quantitative assessment of corrosion product deposits in tissues.
  • To enable precise measurement of corrosion product accumulation at the light microscopy level.

Main Methods:

  • Paraffin embedding of tissue samples (liver, lung) followed by histological sectioning.
  • Thickness standardization of histological sections.

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  • Quantitative analysis using a microscope (MPM-800) and digital image analysis software (DNA-IBAS-Kontron).
  • Assessment of parameters including total field area, deposit count, deposit area, and deposit-to-tissue volume ratio.

    • Main Results:

    • A method was successfully developed for quantitative evaluation of corrosion product deposits in tissues.
    • The method allows for detailed analysis of deposit characteristics at the cellular level.
    • Key quantitative end-points were defined and assessed.

    Conclusions:

    • The proposed method provides a reliable way to quantitatively evaluate corrosion product deposition in tissues.
    • This technique is valuable for assessing the biological response to metallic implants.
    • It supports research in biomaterials and implantology by offering a precise analytical tool.