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Updated: Aug 21, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Thiazolyl and isothiazolyl azomethine derivatives with anti-inflammatory and antioxidant activities
Athina Geronikaki1, Paola Vicini, Matteo Incerti
1Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, Thessaloniki, Greece. geronik@pharm.auth.gr
Abstract:
Several thiazolyl/benzothiazolyl/benzo[d]isothiazolyl Schiff bases and hydrazones have been tested as anti-inflammatory agents and five new compounds have been synthesized. The anti-inflammatory activity was examined in vivo using the carrageenin induced mice paw edema test (inhibition 16.3-64%). The compounds were tested for antioxidant activity as hydroxyl scavengers and for their ability to interact with the stable free radical 1,1-diphenyl-2-picryl-hydrazyl (DPPH). Both anti-inflammatory and antioxidant activities depended on some structural characteristics of the synthesized compounds.
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