Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Galectin-3 does not reliably distinguish benign from malignant thyroid neoplasms.

P Mehrotra¹, A Okpokam, R Bouhaidar

¹School of Surgical and Reproductive Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, UK.

|October 27, 2004

Summary

Galectin-3 is not a reliable marker for distinguishing benign from malignant thyroid lesions. While present in many thyroid cancers, it is also found in non-cancerous conditions, limiting its diagnostic utility.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

BEECH: a dose-finding run-in followed by a randomised phase II study assessing the efficacy of AKT inhibitor capivasertib (AZD5363) combined with paclitaxel in patients with estrogen receptor-positive advanced or metastatic breast cancer, and in a PIK3CA mutant sub-population.

Annals of oncology : official journal of the European Society for Medical Oncology·2019

Same author

Annual hospitalization rates for children with asthma are inversely associated with total hours of sunshine in English regions.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2017

Same author

Bespoke video vignettes - an approach to enhancing reflective learning developed by dental undergraduates and their clinical teachers.

European journal of dental education : official journal of the Association for Dental Education in Europe·2015

Same author

Cellulolytic bacteria as primary colonizers ofPotamogeton pectinatus L. (Sago Pond Weed) from a Brackish South-Temperate Coastal Lake.

Microbial ecology·2013

Same author

Why do general dental practitioners become involved in clinical teaching? A pilot study exploring the views of part-time practitioner teachers, King's College London.

British dental journal·2013

Same author

An act of faith.

British dental journal·2013

Area of Science:

Endocrinology
Oncology
Pathology

Background:

Galectin-3 has been proposed as a potential biomarker for thyroid malignancy.
Distinguishing between benign and malignant thyroid nodules is crucial for appropriate patient management.

Purpose of the Study:

To evaluate the diagnostic accuracy of galectin-3 expression in differentiating thyroid carcinomas from benign follicular lesions.
To assess galectin-3 as a sensitive indicator for thyroid malignancy in preoperative fine-needle aspirates (FNAs).

Main Methods:

Immunohistochemistry was used to assess galectin-3 protein expression in 124 formalin-fixed thyroid tissue samples.
Samples included papillary carcinoma, follicular carcinoma, follicular adenoma, and multinodular goitre.
Western blotting was performed on 24 fresh thyroid tissues to confirm antibody specificity and protein expression.

Related Experiment Videos

Main Results:

Galectin-3 was expressed in a high percentage of papillary (92%) and follicular (74%) carcinomas.
Significant expression was also observed in follicular adenomas (72%) and multinodular goitres (57%).
Galectin-3 expression was significantly higher in papillary carcinomas compared to benign lesions, but not significantly different in follicular carcinomas versus follicular adenomas.

Conclusions:

Galectin-3 is not a reliable immunohistochemical marker for distinguishing benign from malignant thyroid follicular lesions.
The overlap in expression between malignant and benign thyroid conditions limits its utility as a standalone diagnostic marker.