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Association of thyroid disease with acute leukemia
C Moskowitz1, J P Dutcher, P H Wiernik
1Department of Medicine, Albert Einstein College of Medicine, Albert Einstein Cancer Center, Bronx, New York.
American Journal of Hematology
|February 1, 1992
Summary
This study found a threefold increase in autoimmune thyroid disease among acute leukemia patients. Interestingly, Graves
Area of Science:
- Endocrinology
- Hematology
- Oncology
Background:
- Autoimmune thyroid disease (AITD) and acute leukemia are significant health concerns.
- Understanding potential associations between these conditions is crucial for patient management and research.
- Thyroid hormones play a role in hematopoiesis, suggesting a biological link.
Purpose of the Study:
- To investigate the clinical association between autoimmune thyroid disease and acute leukemia.
- To determine the incidence of thyroid disease in patients with acute leukemia.
- To explore the impact of this association on patient outcomes.
Main Methods:
- Retrospective review of adult patients diagnosed with acute leukemia between 1978 and 1989.
- Evaluation of patients with co-existing leukemia and thyroid disease.
- Categorization of leukemia types and specific thyroid disease entities.
Main Results:
- A 3-fold increased incidence of thyroid disease was observed in 27 out of 870 acute leukemia patients.
- Common thyroid conditions included hypothyroidism, Graves' disease, and Hashimoto's thyroiditis.
- Patients with Graves' disease and Hashimoto's thyroiditis showed improved leukemia outcomes, unlike elderly patients.
Conclusions:
- There is a notable association between autoimmune thyroid disease and acute leukemia.
- The specific thyroid conditions, Graves' disease and Hashimoto's thyroiditis, may positively influence leukemia prognosis.
- Further research into the mechanisms of growth regulation in leukemia, involving thyroid hormone receptors, is warranted.