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Protein-bound cobalamin absorption declines in the elderly.

J D Scarlett1, H Read, K O'Dea

  • 1Department of Haematology, Geelong Hospital, Victoria, Australia.

American Journal of Hematology
|February 1, 1992
PubMed
Summary
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Dietary cobalamin absorption declines with age, particularly in those over 75. This study found reduced absorption in healthy elderly individuals, limiting the test

Area of Science:

  • Nutritional biochemistry
  • Geriatric medicine
  • Gastroenterology

Background:

  • Cobalamin (vitamin B12) is essential for numerous physiological processes.
  • Age-related changes can affect nutrient absorption, including cobalamin.
  • Accurate assessment of cobalamin absorption is crucial for diagnosing deficiencies.

Purpose of the Study:

  • To evaluate dietary cobalamin absorption in different age groups of healthy adults.
  • To assess cobalamin absorption in patients with isolated low serum cobalamin concentrations.
  • To investigate the relationship between cobalamin absorption, age, and serum gastrin levels.

Main Methods:

  • Utilized a modified protein-bound cobalamin absorption test.
  • Studied absorption in young adults, healthy elderly individuals (55-75 and >75 years), and patients with low serum cobalamin.

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Main Results:

  • Dietary cobalamin absorption significantly decreased in healthy adults aged 55-75 and further in those over 75.
  • No significant difference in absorption was found between patients with low serum cobalamin and age-matched controls.
  • Reduced cobalamin malabsorption correlated with elevated serum gastrin levels.

Conclusions:

  • Cobalamin absorption naturally declines with aging.
  • The modified protein-bound cobalamin absorption test has limited diagnostic utility in the elderly due to reduced absorption in healthy individuals.
  • Further evaluation of absorption tests across different age groups is recommended before clinical application.