Related Experiment Video
Updated: Aug 21, 2026
Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies
Published on: October 6, 2022
Spinal neural cyclooxygenase-2 mediates pain caused in a rat model of lumbar disk herniation
Seiji Ohtori1, Kazuhisa Takahashi, Yasuchika Aoki
1Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University School of Medicine, Chiba University, Chiba, Japan. sohtori@faculty.chiba-u.jp
Unlabelled:
Application of nucleus pulposus to nerve root generates radicular pain. We demonstrated that these animals showed allodynia for 2 weeks, and cyclooxygenase-2 (COX-2) immunoreactivities were up-regulated in the spinal dorsal horn. COX-2 immunoreactivities were shown in neurons; however, they were not in astrocytes. Intrathecal administration of an antibody to COX-2 decreased allodynia. Our results suggest that COX-2 in spinal cord might be a target for treatment of patients with nerve root pain caused by lumbar disk herniation.
Perspective:
Neural COX-2 might mediate nerve root pain in the spinal cord caused by lumbar disk herniation in rats.
