Socially mediated alcohol preferences in adolescent rats following interactions with an intoxicated peer

This study focuses on "passive social influences" (alcohol-related information acquired by an organism that interacts with an intoxicated counterpart) that can potentially affect alcohol preference in adolescent rats. Five experiments were conducted to investigate whether repeated social interactions with an intoxicated peer can generate alcohol-related memories that lead an animal to exhibit heightened alcohol olfactory preference patterns. Juvenile experiences with alcohol were operationalized as follows: interactions with an alcohol-intoxicated peer (Experiment 1), with an alcohol-scented cotton surrogate (Experiment 2) or with an anesthetized alcohol-intoxicated partner (Experiments 3-5). Periadolescents were then evaluated in a two-way location olfactory test where they had the opportunity to investigate a hole scented with alcohol odor or vanilla (an odorant naturally preferred by the strain of rats here utilized). Only juveniles that interacted with an alcohol-intoxicated peer were found to exhibit a significant change in alcohol odor preferences when compared to appropriate controls that interacted with a non-intoxicated peer. Alcohol odor exposure alone or interactions with an anesthetized alcohol-intoxicated peer were not sufficient to establish changes in preference for alcohol sensory cues. Results indicate that social interactions with an intoxicated peer determine heightened preference for alcohol cues in periadolescents. The establishment of this preference seems to require behavioral manifestations of the intoxicated counterpart, instead of just being dependent on an olfactory pre-exposure to alcohol cues.