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Related Experiment Videos

Intraperitoneal leptin modifies macronutrient choice in self-selecting rats.

Sandrine Wetzler1, Valérie Dumaz, Marc Goubern

  • 1UMR INRA/INAPG 914 Physiologie de la Nutrition et du Comportement Alimentaire Institut National Agronomique de Paris-Grignon, 16, rue Claude Bernard. 75231 Paris Cedex 05, France.

Physiology & Behavior
|October 27, 2004
PubMed
Summary

Leptin administration in rats reduced food intake and body weight gain. It also altered macronutrient preferences, affecting protein and carbohydrate intake, and increased thermogenesis.

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Area of Science:

  • Endocrinology
  • Nutritional Science
  • Metabolism

Background:

  • Leptin is a key hormone regulating energy balance.
  • Understanding leptin's effects on macronutrient selection is crucial for metabolic research.

Purpose of the Study:

  • To investigate the impact of acute and chronic leptin administration on food intake, body weight, and macronutrient selection in rats.
  • To examine the influence of leptin on energy expenditure, specifically brown adipose tissue (BAT) thermogenesis.

Main Methods:

  • Rats received acute intraperitoneal leptin injections or chronic leptin infusion.
  • Macronutrient intake (protein, fat, carbohydrate) and body weight gain were monitored.
  • Brown adipose tissue (BAT) thermogenesis was assessed.

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Main Results:

  • Acute leptin injections reduced 24-h food intake and body weight gain.
  • Chronic leptin infusion decreased overall intake, primarily affecting protein, while fat intake showed a slight increase.
  • Carbohydrate intake proportion decreased in carbohydrate-preferring rats, and BAT thermogenesis was elevated.

Conclusions:

  • Leptin influences food intake, body weight, and macronutrient preferences, impacting both energy intake and expenditure.
  • The effects of leptin vary with administration type (acute vs. chronic) and age, potentially indicating age-related leptin resistance.