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Shiga toxin binding to isolated porcine tissues and peripheral blood leukocytes
Kellie R K Winter1, William C Stoffregen, Evelyn A Dean-Nystrom
1Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, USDA Agricultural Research Service, National Animal Disease Center, Ames 50010-0070, USA.
Abstract:
Shiga toxin (Stx) binding sites in porcine tissues and leukocytes were identified by the use of Stx overlay and anti-CD77/Gb3 immunoassays. Stx1 and Stx2 bound to similar tissue locations and leukocytes, although some differences were noted. Previously unreported Stx binding sites were identified in kidney tubules, intestinal lymphoid aggregates, sinusoidal liver cells, alveolar macrophages, and peripheral blood leukocytes.
