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Interleukin-15-deficient mice develop protective immunity to Toxoplasma gondii
Linda A Lieberman1, Eric N Villegas, Christopher A Hunter
1Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA.
Infection and Immunity
|October 27, 2004
Abstract:
Previous studies have suggested an important role for interleukin-15 (IL-15) in resistance to and memory for Toxoplasma gondii infection. The studies presented here reveal that IL-15 is not required for infection-induced expansion of NK or CD8+ T cells. Furthermore, IL-15-/- mice develop long-term protective immunity to this pathogen.