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Published on: June 2, 2018
Transcriptional coactivator p300/CBP-associated factor and p300/CBP-associated factor type B are required for normal
Erina Inoue1, Miho Hanai, Kazuhiko Yamada
1Division of Applied Food Research, National Institute of Health and Nutrition, Shinjuku, Tokyo 162-8636, Japan.
Abstract:
Mice with targeted gene disruption of one of the estrogen receptor coactivators, p300/CBP-associated factor (PCAF), and its counterpart, PCAF-B, were used to investigate the possible involvement of PCAF and PCAF-B in estrogen receptor-mediated actions in vivo. Among ovariectomized mice that were treated with estrogen, PCAF and PCAF/PCAF-B knockouts showed abnormal growth of the uterus compared with the wild type. The level of c-fos gene expression in the uterus was not induced by estrogen in the knockouts. These observations suggest that PCAF and PCAF-B are required for estrogen-dependent normal growth of the uterus via estrogen receptor-mediated transcriptional regulations.
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