Plasma homocysteine, MTHFR C677T, CBS 844ins68bp, and MTHFD1 G1958A polymorphisms in spontaneous cervical artery

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Carsten Konrad1, Georg A Müller, Claus Langer

  • 1Department of Neurology, University of Münster, Albert-Schweitzer-Str. 11, 48149 Münster, Germany. konradc@uni-muenster.de

Journal of Neurology
|October 27, 2004
PubMed

Insights

Elevated homocysteine levels are linked to spontaneous cervical artery dissections (sCAD). While the MTHFR 677 TT genotype affects homocysteine, it

Area of Science:

  • Cardiovascular Research
  • Neurology
  • Genetics

Background:

  • Mild hyperhomocysteinemia is a potential risk factor for atherosclerotic diseases and stroke.
  • Previous studies suggested a link between elevated homocysteine and the MTHFR 677 TT genotype with spontaneous cervical artery dissections (sCAD).

Purpose of the Study:

  • To investigate the association between elevated plasma homocysteine and sCAD in the largest patient cohort to date.
  • To analyze the influence of known factors on plasma homocysteine levels in sCAD patients.

Main Methods:

  • Compared 95 sCAD patients with 95 age- and sex-matched healthy controls.
  • Assessed homocysteine, vitamin B6, B12, folate levels, and MTHFR C677T, CBS 844ins68bp, MTHFD1 G1958A genotypes.
  • Utilized multivariate statistics to analyze associations.

Main Results:

  • sCAD occurrence was associated with elevated homocysteine levels (OR 1.327 per 20% percentile).
  • Homocysteine levels were influenced by gender, smoking, hypertension, vitamin B12, folate, and MTHFR TT genotype.
  • MTHFR, CBS, and MTHFD1 genotypes were not independently associated with sCAD occurrence.

Conclusions:

  • Elevated homocysteine is associated with the occurrence of sCAD.
  • The MTHFR C677T polymorphism is associated with homocysteine levels but not independently with sCAD.

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