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Dermatofibrosarcoma protuberans
William M Mendenhall1, Robert A Zlotecki, Mark T Scarborough
1Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, Florida, USA. mendewil@shands.ufl.edu
Abstract:
In the current review, the authors set out to discuss the natural history and treatment of dermatofibrosarcoma protuberans (DFSP), a rare indolent cutaneous tumor. Approximately 10-15% of all DFSPs contain areas of fibrosarcoma (DFSP-FS), and such cases tend to exhibit more aggressive behavior. The optimal treatment for DFSP is resection with wide margins; the likelihood of local control associated with this procedure exceeds 90%. The probability of regional or distant metastases is /= 85% in such patients. Postoperative radiotherapy also is indicated in the rare event that a patient has unresectable macroscopic disease. Experience with the use of radiotherapy alone to treat macroscopic disease is limited.