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Myocardial dysfunction in ankylosing spondylitis.

B A Gould1, J Turner, D H Keeling

  • 1Department of Cardiology, Plymouth Group of Hospitals, United Kingdom.

Annals of the Rheumatic Diseases
|February 1, 1992
PubMed
Summary
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Patients with ankylosing spondylitis exhibit subtle cardiac abnormalities, particularly in diastolic function. This study reveals decreased left ventricular compliance in AS patients compared to healthy individuals.

Area of Science:

  • Cardiology
  • Rheumatology
  • Medical Imaging

Background:

  • Ankylosing spondylitis (AS) is a chronic inflammatory disease.
  • Previous echocardiographic studies suggested myocardial dysfunction in AS patients.
  • Cardiac involvement in AS requires further investigation.

Purpose of the Study:

  • To evaluate cardiac function in patients with ankylosing spondylitis (AS) compared to normal volunteers.
  • To identify specific abnormalities in myocardial function in AS patients.
  • To assess diastolic function and left ventricular compliance in AS.

Main Methods:

  • Cardiac function assessed using echocardiography and radionuclide angiography at rest and during supine bicycle exercise.
  • 21 AS patients and 24 healthy volunteers (aged 18-45) participated.

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  • Subjects were matched for age, sex, height, and weight.

    • Main Results:

    • No significant echocardiographic differences were observed between groups.
    • Radionuclide angiography revealed significant differences in global left ventricular function.
    • Patients with AS showed a lower peak filling rate and altered time to peak filling during exercise.
    • Regional analysis indicated reduced filling fraction and peak filling rate in the anteroseptal region of AS patients.
    • Most observed abnormalities were related to diastolic function.

    Conclusions:

    • Subtle abnormalities in cardiac function exist in patients with ankylosing spondylitis.
    • The primary abnormalities are in diastolic function, indicating reduced left ventricular compliance.
    • These findings highlight the importance of cardiac monitoring in AS patients.