Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fast three-dimensional numerical hemolysis approximation.

André Garon1, Marie-Isabelle Farinas

  • 1Département de Génie Mécanique, Ecole Polytechnique de Montréal, Montréal, Quebec, Canada.

Artificial Organs
|October 27, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

On the flow separation in the wake of a fixed and a rotating cylinder.

Chaos (Woodbury, N.Y.)·2015
Same author

Comparison and analysis of three different methods to evaluate vertical jump height.

Clinical physiology and functional imaging·2014
Same author

New equations for the dose under pulsative/periodic conditions in the design of coated stents.

Computer methods in biomechanics and biomedical engineering·2009
Same author

Mechanical hemolysis in blood flow: user-independent predictions with the solution of a partial differential equation.

Computer methods in biomechanics and biomedical engineering·2008
Same author

Structure of large arteries: orientation of elastin in rabbit aortic internal elastic lamina and in the elastic lamellae of aortic media.

Microvascular research·2006
Same author

Asymptotically consistent numerical approximation of hemolysis.

Journal of biomechanical engineering·2006
Same journal

Large-Eddy Simulation of the FDA Benchmark Blood Pump: Validation Against Experiments and Implications for Turbulent Flow Mechanisms.

Artificial organs·2026
Same journal

The Warm Revolution: A Meta-Analysis of DCD Versus DBD Liver Transplant Outcomes in the Normothermic Machine Perfusion Era.

Artificial organs·2026
Same journal

Toward Optimal Remote Monitoring in LVAD Recipients: Remaining Challenges Beyond Feasibility.

Artificial organs·2026
Same journal

Advancing Organ Preservation and Perfusion: Introducing the International Society of Organ Preservation and Perfusion Therapy (ISOPPT).

Artificial organs·2026
Same journal

Short Inter-Treatment Interval Treatment With Artificial Liver Support System Reduces 90-Day Transplant-Free Mortality in Patients With Hepatitis B Virus-Related Acute-On-Chronic Liver Failure: A Retrospective Observational Study.

Artificial organs·2026
Same journal

Extracorporeal Albumin Dialysis (OPAL) as Novel Therapeutic Bridging Option in Posthepatectomy Liver Failure.

Artificial organs·2026
See all related articles

This study introduces a new numerical method to predict medical device-induced hemolysis, aiming to minimize red blood cell damage during device design. The approach uses a novel volume integration technique for accurate hemolysis prediction.

Area of Science:

  • Biomedical Engineering
  • Fluid Mechanics
  • Hematology

Background:

  • Mechanical device implantation can cause hemodynamic disturbances, leading to red blood cell damage and hemolysis.
  • Assessing blood compatibility early in the design phase is crucial for medical devices.
  • Existing in vivo hemolysis indices are lacking, necessitating reliance on in vitro standards.

Purpose of the Study:

  • To develop a numerical framework for predicting medical device-induced hemolysis.
  • To minimize red blood cell damage by optimizing device design.
  • To create a predictive tool analogous to in vitro hemolysis testing.

Main Methods:

  • A novel interpretation of the Giersiepen-Wurzinger blood damage correlation was employed.
  • Blood damage computation was shifted from streamline analysis to volume integration.

Related Experiment Videos

  • The methodology was validated using three-dimensional computational examples.

    • Main Results:

    • The developed numerical method provides a framework for predicting device-induced hemolysis.
    • The volume integration approach offers an alternative to streamline-based damage computation.
    • The accuracy and behavior of the methodology were assessed through 3D simulations.

    Conclusions:

    • The proposed numerical method can aid in minimizing hemolysis caused by medical devices.
    • This predictive framework facilitates the design of blood-innocuous mechanical devices.
    • The study advances computational approaches for assessing blood-biomaterial interactions.