Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Modeling centrifugal cell washers using computational fluid dynamics.

Beth E Kellet1, Binbing Han, David S Dandy

  • 1Department of Chemical Engineering, Colorado State University, Fort Collins, CO 80523, USA.

Artificial Organs
|October 27, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Detection of Aerosolized Protein Using a Condensation Growth Tube Coupled with an Electrochemical Immunoassay on Screen-Printed Carbon Electrodes.

Analytical chemistry·2026
Same author

Capillary-Driven Duplex Microfluidic Device Enabling Simultaneous Electrochemical Immunoassays for Detecting SARS-CoV-2 and Respiratory Syncytial Virus.

ACS sensors·2026
Same author

Membrane Separation for Rare Earth Elements (A Review).

Membranes·2026
Same author

Membrane technology for resource recovery.

Water research·2026
Same author

Performance of large virus removal filters during AAV processing: Influence of flux and process disruptions.

Biotechnology progress·2026
Same author

Downstream Process Intensification for AAV Purification by Affinity Chromatography Using Single Pass Tangential Flow Filtration.

Biotechnology and bioengineering·2025
Same journal

Large-Eddy Simulation of the FDA Benchmark Blood Pump: Validation Against Experiments and Implications for Turbulent Flow Mechanisms.

Artificial organs·2026
Same journal

The Warm Revolution: A Meta-Analysis of DCD Versus DBD Liver Transplant Outcomes in the Normothermic Machine Perfusion Era.

Artificial organs·2026
Same journal

Toward Optimal Remote Monitoring in LVAD Recipients: Remaining Challenges Beyond Feasibility.

Artificial organs·2026
Same journal

Advancing Organ Preservation and Perfusion: Introducing the International Society of Organ Preservation and Perfusion Therapy (ISOPPT).

Artificial organs·2026
Same journal

Short Inter-Treatment Interval Treatment With Artificial Liver Support System Reduces 90-Day Transplant-Free Mortality in Patients With Hepatitis B Virus-Related Acute-On-Chronic Liver Failure: A Retrospective Observational Study.

Artificial organs·2026
Same journal

Extracorporeal Albumin Dialysis (OPAL) as Novel Therapeutic Bridging Option in Posthepatectomy Liver Failure.

Artificial organs·2026
See all related articles

Computational fluid dynamics (CFD) can optimize centrifuge design for washing surgical shed blood, reducing the need for transfusions. This approach aids in developing more efficient blood processing technologies.

Area of Science:

  • Biomedical Engineering
  • Fluid Dynamics
  • Surgical Innovation

Background:

  • Autologous reinfusion of shed blood during surgery can eliminate the need for allogeneic blood transfusions.
  • Processing shed blood requires washing to remove contaminants like leukocytes and platelets, followed by hematocrit increase.
  • Current centrifuge designs for blood processing may not be optimal for efficiency and contaminant removal.

Purpose of the Study:

  • To explore the feasibility of using computational fluid dynamics (CFD) to guide the design of improved centrifuges for processing surgical shed blood.
  • To analyze the velocity field within a centrifuge bowl and quantify protein removal rates during shed blood processing.

Main Methods:

  • Computational fluid dynamics (CFD) simulations were employed to model fluid flow within a centrifuge bowl.

Related Experiment Videos

  • The simulations focused on analyzing the velocity field and predicting the efficiency of contaminant removal, specifically proteins.
  • The study aimed to validate CFD as a tool for preliminary centrifuge bowl design screening.

    • Main Results:

    • CFD simulations provided insights into the velocity distribution within the centrifuge bowl during shed blood processing.
    • The study successfully modeled and predicted the rate of protein removal, a key indicator of contaminant clearance.
    • Results suggest CFD can effectively screen initial centrifuge bowl designs, reducing experimental iterations.

    Conclusions:

    • Computational fluid dynamics is a viable tool for optimizing centrifuge bowl design in blood processing.
    • CFD analysis can accelerate the development of more efficient devices for washing surgical shed blood.
    • The developed CFD methods are applicable to the broader field of blood processing centrifuge design.