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Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance
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Plasmid-mediated carbapenem-hydrolyzing enzyme KPC-2 in an Enterobacter sp

Ashfaque Hossain1, M J Ferraro, R M Pino

  • 1Department of Medical Microbiology and Immunology, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA.

Antimicrobial Agents and Chemotherapy
|October 27, 2004
PubMed

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Plasmids01:28

Plasmids

Plasmids are extrachromosomal DNA molecules found in bacteria, archaea, and some eukaryotic microbes like yeast. These small, circular DNA structures typically contain fewer than 30 genes, although some may exist linearly. Plasmids vary in their number within a cell, known as copy number. Single-copy plasmids are present in one copy per cell and multi-copy plasmids are present in multiple copies, reaching over 100 copies per cell.Plasmids usually replicate independently of the chromosomal DNA...