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Updated: Aug 19, 2026
An Orthotopic Murine Model of Human Prostate Cancer Metastasis
Published on: September 19, 2013
TGFBR1*6A is not associated with prostate cancer in men of European ancestry
1Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 S Euclid, St Louis, M) 63110, USA. bks@themfs.wustl.edu
Abstract:
The TGFBR1*6A (*6A) variant in exon 1 of the TGFBR1 gene has been postulated as a putative tumor susceptibility allele in several studies. We have performed a case-control study in 537 men with histologically verified prostate cancer and in 488 unrelated controls to investigate the association of *6A with prostate cancer. Our results revealed that the frequency of the (*)6A allele does not differ in men with prostate cancer compared to healthy controls, even in a subset of age-matched cases and controls. There is no compelling evidence for an association of the *6A variant with prostate cancer.
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