Related Experiment Video
Updated: Aug 21, 2026
Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease
Published on: May 22, 2026
Assessment of diastolic function in patients with hypertrophic cardiomyopathy by Doppler tissue imaging
Jing Li1, Yan-ling Liu, Hao Wang
1Department of Ultrasound, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037.
Insights
Pulsed Doppler tissue imaging effectively assesses left ventricular diastolic function. Early diastolic mitral annular velocities best distinguish hypertrophic cardiomyopathy patients from healthy individuals.
Area of Science:
- Cardiology
- Echocardiography
- Diastology
Background:
- Left ventricular diastolic dysfunction is a key indicator of cardiac health.
- Hypertrophic cardiomyopathy (HCM) often presents with diastolic dysfunction.
- Accurate assessment of diastolic function is crucial for patient management.
Purpose of the Study:
- To evaluate the clinical utility of pulsed Doppler tissue imaging (DTI).
- To assess DTI's ability to measure left ventricular diastolic function.
- To differentiate between normal subjects and HCM patients with varying diastolic dysfunction.
Main Methods:
- Doppler tissue imaging was used to measure peak diastolic mitral annular velocities.
- 81 HCM patients and 50 healthy volunteers were studied.
- Measurements were obtained from apical views using a 2-chamber and long-axis approach.
Main Results:
- Normal subjects exhibited higher early diastolic mitral annular velocities than HCM patients.
- This difference was observed across all stages of diastolic dysfunction in HCM.
- Peak velocities during atrial contraction were comparable between groups.
Conclusions:
- Pulsed Doppler tissue imaging directly reflects left ventricular diastolic function.
- The early diastolic phase is a critical differentiator between normal and HCM subjects.
- DTI provides valuable insights into diastolic mechanics in HCM.
Objective:
To determine the clinical application of pulsed Doppler tissue imaging in assessing the left ventricular diastolic function and in discriminating between normal subjects and patients with hypertrophic cardiomyopathy with various stages of diastolic dysfunction.
Methods:
We measured the peak diastolic velocities of mitral annulus in 81 patients with hypertrophic cardiomyopathy with various stages of diastolic dysfunction and 50 normal volunteers by Doppler tissue imaging using the apical window at 2-chamber and long apical views, respectively. The myocardial velocities were determined with use of variance F statistical analysis.
Results:
Early diastolic myocardial velocities of mitral annulus were higher in normal subjects than in patients with hypertrophic cardiomyopathy with either delayed relaxation, pseudonormal filling, or restrictive filling. However, peak myocardial velocities of mitral annulus during atrial contraction were similar in normal subjects and patients with hypertrophic cardiomyopathy.
Conclusion:
Doppler tissue imaging can directly reflect upon left diastolic ventricular function. Early phase of diastole was the best discriminator between control subjects and patients with hypertrophic cardiomyopathy.
Related Concept Videos
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
01:19Assessing Blood pressure using a doppler ultrasound
Pre-Procedural Guidelines for Doppler Ultrasound Blood Pressure Assessment:
Preparation of Equipment: