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Updated: Aug 21, 2026

An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions
Published on: March 22, 2018
Oscillations in transcription factor dynamics: a new way to control gene expression
1Centre for Cell Imaging, School of Biological Sciences, Bioscience Research Building, Crown St., University of Liverpool, Liverpool L69 7ZB, UK.
Abstract:
Oscillations in second-messenger signalling (e.g. calcium) have previously been shown to be important in the control of transcription. More recently, oscillations in localization and absolute levels of transcription factors and their regulators have been identified. Here we discuss the role of network motifs such as the negative feedback loop and their role in oscillatory signalling, and how oscillations in components of the nuclear factor kappaB signalling pathway are important to the dynamic control of transcription in response to a cytokine stimulus.
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