Annotating significant pairs of transcription factor binding sites in regulatory DNA
Katja Rateitschak1, Tobias Müller, Martin Vingron
1Max Planck Institute for Molecular Genetics, Ihnestr. 73, D-14195 Berlin, Germany. Katja.Rateitschak@molgen.mpg.de
Abstract:
In the presented work we search for transcription factor binding sites (BS) by including additional information about typical BS patterns. The new proposed score combines the ordinary profile score based on TRANSFAC-matrices together with a score based on pairs of BS. The latter score positively weights pairs of BS that tend to occur together in many regulatory DNA-sequences, in contrast to a random background model. The empirical BS pair frequencies result from our evaluation of a large dataset of orthologous genes.
More Related Videos
21:55Chromatin Interaction Analysis with Paired-End Tag Sequencing (ChIA-PET) for Mapping Chromatin Interactions and Understanding Transcription Regulation
Published on: April 30, 2012
11:34Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
Published on: August 9, 2019
Related Concept Videos
Cooperative Binding of Transcription Regulators
Cooperative Binding of Transcription Regulators
Cis-regulatory Sequences
Cis-regulatory Sequences
Co-activators and Co-repressors
Co-activators and Co-repressors
