Antibody-mediated interference with annexins in the antiphospholipid syndrome
1Hematology Laboratory Montefiore Medical Center Core Laboratory Office, North 8, 111 East 210th Street, Bronx, NY 10467, USA. jrand@montefiore.org
Abstract:
Targeting of the annexin A5 anticoagulant shield may be a significant mechanism for thrombosis and pregnancy losses in APS. This may occur via high affinity antibodies that recognize phospholipid-binding proteins that are capable of interfering with the assembly of the annexin A5 shield on phospholipid surfaces or via direct recognition of annexin A5 by autoantibodies. In addition, antibodies against other members of the annexin family of proteins may also have pathogenic roles in APS. It is anticipated that further research will elucidate the biologic functions of these proteins and their roles in the aPL disease processes.
Related Concept Videos
Antibody Actions
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
Phosphoinositides and PIPs
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
Hypersensitivity Reactions: Cytolytic Reactions
Intracellular Signaling Affects Focal Adhesions
Some...
Affinity and Avidity
Anticoagulant Drugs: Low-Molecular-Weight Heparins

