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Related Experiment Videos

Consensus guidelines for anticardiolipin antibody testing.

Richard C W Wong1,

  • 1Division of Immunology, Queensland Health Pathology Services, Princess Alexandra and Royal Brisbane Hospitals, 1st Floor, Building 15, Woolloongabba, QLD 4102, Australia. richard_wong@health.qld.gov.au

Thrombosis Research
|October 28, 2004
PubMed
Summary
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Standardized anticardiolipin antibody (aCL) testing faces challenges due to inter-laboratory variation. This review examines guidelines to improve aCL test consistency, accuracy, and clinical utility.

Area of Science:

  • Immunology
  • Clinical Chemistry

Background:

  • Significant inter-laboratory and inter-method variation exists in anticardiolipin antibody (aCL) testing, despite standardized units.
  • This variability limits the clinical utility and portability of aCL test results across different laboratories.

Purpose of the Study:

  • To review existing guidelines for improving anticardiolipin antibody (aCL) testing.
  • To enhance the consistency of aCL results between laboratories, assays, and testing runs.

Main Methods:

  • Review of published and unpublished guidelines.
  • Analysis of guidelines pertaining to specimen collection, assay manufacturing, testing procedures, quality control, and result interpretation.

Main Results:

  • Guidelines exist to improve various aspects of aCL testing, including specimen handling, assay procedures, quality control, and reporting.

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  • Implementation of these guidelines can enhance the consistency of aCL test results.

    • Conclusions:

    • While guidelines can improve specific aspects of aCL testing, a need persists for comprehensive consensus guidelines.
    • Consolidated guidelines are required to address all facets of aCL testing and reporting for improved standardization.