Related Experiment Videos
Recurrent infusion phlebitis induced by cyclosporine
Yakir Rottenberg1, Zvi G Fridlender
1Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
The Annals of Pharmacotherapy
|October 28, 2004
Summary
This case report details recurrent infusion phlebitis during cyclosporine treatment, a previously unreported adverse effect. Physicians should consider this risk when prescribing cyclosporine for ulcerative colitis or other conditions.
Area of Science:
- Pharmacology
- Gastroenterology
- Clinical Medicine
Background:
- Ulcerative colitis management often involves immunosuppressive agents.
- Cyclosporine is used in severe cases of ulcerative colitis.
- Infusion phlebitis is a known complication of certain intravenous therapies.
Observation:
- A 28-year-old male with ulcerative colitis developed severe, recurrent infusion phlebitis during intravenous cyclosporine therapy.
- Frequent catheter replacement was necessary due to phlebitis.
- The patient achieved remission of ulcerative colitis despite the adverse effect.
Findings:
- This is the first reported case of cyclosporine-induced recurrent infusion phlebitis.
- The Naranjo probability scale suggests a probable link between cyclosporine and phlebitis.
- The patient experienced no long-term venous damage after 8 months of follow-up.
Implications:
- Cyclosporine-induced infusion phlebitis is a novel adverse effect requiring clinical consideration.
- Awareness of this potential complication is crucial for patient safety during cyclosporine treatment.
- Further research may be warranted to understand the mechanism and incidence of this adverse effect.