Contribution of peroxidases in host-defense, diseases and cellular functions

Peroxidases figure prominently in biology and contribute significantly to cell biology, host defense against infection, and pathogenesis of several inflammatory diseases. These varied and diverse aspects of peroxidase biochemistry and its clinical implications will be the subjects of in-depth analysis at the 4th International peroxidase meeting held in Kyoto. Specific topics range from the molecular basis of peroxidase structure and function to the clinical consequences of autoantibodies generated against myeloperoxidase (MPO), the peroxidase present in circulating neutrophils. Consideration of novel aspects of peroxidase biology, both unanticipated biochemical properties of MPO and the potential role of MPO in the pathogenesis of inflammatory diseases such as atherosclerosis, will also be included. In addition to peroxidases, the newly expanded family of NADPH oxidases will be discussed. We hope that this collection of scientists who share a common interest in peroxidase biology but each possess expertise in distinctly different aspects of the subject will provide a setting for spirited discussion and a lively exchange of views to yield advances in understanding and to create new applications of those insights to benefit clinical medicine, agriculture and industry.