Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lessons from MPO deficiency about functionally important structural features.

William M Nauseef1

  • 1Inflammation Program and Department of Medicine, University of Iowa, Veterans Administration Medical Center, Iowa, USA. william-nauseef@uiowa.edu

Japanese Journal of Infectious Diseases
|October 28, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Myeloperoxidase gene knockout causes local inflammation and dysbiosis in the murine gut.

Gut microbes reports·2025
Same author

Remembering Neil Reiner, MD.

Journal of leukocyte biology·2025
Same author

Mutation in Staphylococcus aureus that supports gain of function in susceptibility both to hypochlorous acid and to human neutrophils.

Journal of leukocyte biology·2025
Same author

Challenging the role of a NOX4-Piezo1 axis in neutrophil bactericidal function.

Immunity·2024
Same author

Neutrophil defect and lung pathogen selection in cystic fibrosis.

Journal of leukocyte biology·2023
Same author

Neutrophils and their friends.

Immunological reviews·2023
Same journal

Invasive Infection Caused by a Hypervirulent ST367-KL1 Klebsiella quasipneumoniae subsp. similipneumoniae: First Case Report in Japan.

Japanese journal of infectious diseases·2026
Same journal

Lung regulatory T cells and inflammatory mediators associate with heterogeneous outcomes in a SARS-CoV-2 infected mouse model.

Japanese journal of infectious diseases·2026
Same journal

A multi-prefecture rubella outbreak associated with technical intern training for foreign workers in Japan, 2016: Implications for sustaining rubella elimination verified in 2025.

Japanese journal of infectious diseases·2026
Same journal

Validation of a Novel ELISA and Immunochromatography Assay for Tetanus Antibody Detection.

Japanese journal of infectious diseases·2026
Same journal

Disease burden and quality of life in caregivers of infants with RSV lower respiratory tract infections in Japan.

Japanese journal of infectious diseases·2026
Same journal

Pre- vaccination seroprevalence of rubella IgM among women of child bearing age in southeast Nigeria: a five-year cross-sectional study.

Japanese journal of infectious diseases·2026
See all related articles

Studying genetic mutations causing myeloperoxidase deficiency reveals crucial details about normal enzyme function. These "experiments of nature" illuminate the underlying principles of myeloperoxidase biosynthesis.

Area of Science:

  • Biochemistry
  • Genetics
  • Molecular Biology

Background:

  • Genetic abnormalities offer unique insights into normal biological processes.
  • Studying inherited disorders can elucidate fundamental cellular mechanisms.

Purpose of the Study:

  • To investigate the impact of specific missense mutations on myeloperoxidase (MPO) biosynthesis.
  • To understand the molecular basis of inherited MPO deficiency.

Main Methods:

  • Analysis of genetic mutations causing inherited MPO deficiency.
  • Examination of MPO biosynthesis pathways.

Main Results:

  • Identified and described three missense mutations associated with MPO deficiency.
  • Characterized the effects of these mutations on MPO biosynthesis.

Related Experiment Videos

Conclusions:

  • Missense mutations leading to MPO deficiency provide critical insights into normal MPO function.
  • These studies enhance understanding of MPO biosynthesis and inherited deficiencies.