Related Experiment Video

Updated: Aug 21, 2026

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
10:03

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

An adult case of Chryseobacterium meningosepticum meningitis

Cheng-Hsien Lu1, Chi-Ren Huang, Nai-Wen Tsai

  • 1Department of Neurology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan.

Japanese Journal of Infectious Diseases
|October 28, 2004
PubMed

Insights

Chryseobacterium meningosepticum meningitis is rare in adults. This case highlights successful cefepime treatment for a 21-year-old woman with diabetes, emphasizing cerebrospinal fluid culture for diagnosis.

Area of Science:

  • Infectious Diseases
  • Neurology
  • Microbiology

Background:

  • Chryseobacterium meningosepticum is an infrequent cause of bacterial meningitis, particularly in adults.
  • Adult meningitis cases caused by this pathogen are uncommon, necessitating specific diagnostic considerations.

Observation:

  • A 21-year-old woman presented with symptoms including fever, headache, altered consciousness, and seizures.
  • The patient had a history of insulin-dependent diabetes mellitus, a potential predisposing factor.
  • Cerebrospinal fluid analysis indicated a purulent inflammatory response.

Findings:

  • Diagnosis was confirmed by positive cerebrospinal fluid culture for Chryseobacterium meningosepticum.
  • Intravenous cefepime at 6 g/day was administered for 21 days.
  • The patient achieved complete recovery following treatment.

Implications:

  • This case underscores the importance of considering uncommon pathogens in adult meningitis.
  • Cerebrospinal fluid culture remains the gold standard for diagnosing C. meningosepticum meningitis.
  • Effective treatment with cefepime can lead to favorable outcomes in affected patients.

Related Concept Videos

Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Bacterial Meningitis01:24

Bacterial Meningitis

Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...