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Related Experiment Videos

ADC mapping of normal human brain.

Frank Ahlhelm1, Thomas Hagen, Guenther Schneider

  • 1Department of Neuroradiology, University of Saarland, Homburg, Germany. frah1@gmx.de

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
|October 28, 2004
PubMed
Summary

Diffusion weighted imaging (DWI) quantifies normal human brain diffusion. Apparent diffusion coefficient (ADC) and anisotropy index (AI) values are constant across individuals, aiding lesion severity assessment.

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Area of Science:

  • Neuroimaging
  • Diffusion Weighted Imaging (DWI)
  • Quantitative MRI

Background:

  • Diffusion weighted imaging (DWI) is crucial for evaluating brain pathologies, particularly hyperacute stroke.
  • Quantification of diffusion conditions in the normal human brain is increasingly important.
  • Understanding physiological diffusion parameters aids in diagnosing cerebral pathologies.

Purpose of the Study:

  • Investigate apparent diffusion coefficient (ADC) and anisotropy index (AI) in the normal human brain.
  • Establish physiological ADC values for ADC mapping across different brain regions.
  • Provide reference values for normal brain diffusion parameters.

Main Methods:

  • Analyzed 22 regions of interest (ROIs) in ADC maps from 53 healthy volunteers.

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  • Measured diffusion parameters in gray matter and white matter of frontal, parietal, and occipital lobes.
  • Included corpus callosum and lateral ventricles in the analysis.

    • Main Results:

    • Apparent diffusion varied significantly across different brain regions.
    • Isotropic diffusion observed in subcortical white matter (ADC: 525 x 10(-8) mm2/s, AI: 0.05) and gray matter (ADC: 1486 x 10(-8) mm2/s, AI: 0.05).
    • Anisotropic diffusion found in periventricular white matter (ADC: 408 x 10(-8) mm2/s, AI: 0.34) and corpus callosum (ADC: 799 x 10(-8) mm2/s, AI: 0.77).

    Conclusions:

    • Apparent diffusion coefficient (ADC) is intra- and interindividually constant in adults, irrespective of sex or age (mean age: 62+/-9.4 years).
    • ADC measurements can serve as an index for lesion severity.
    • Findings provide normative data for ADC and AI in various brain regions.