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Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
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Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

Report of the Australian rotavirus surveillance program 2002-03

Carl D Kirkwood1, Nada Bogdanovic-Sakran, Ruth Clark

  • 1National Rotavirus Reference Centre, Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Road, Parkville, VIC 3052. kirkwooc@mcri.edu.au

Communicable Diseases Intelligence Quarterly Report
|October 29, 2004
PubMed

Insights

Rotavirus surveillance in Australia found G9 strains caused most childhood gastroenteritis hospitalizations for the second year. This impacts vaccine strategies targeting G1-G4 serotypes.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Rotavirus is a leading cause of acute gastroenteritis in children globally.
  • The National Rotavirus Reference Centre has monitored rotavirus strains in Australia since 1999.
  • Understanding circulating serotypes is crucial for vaccine efficacy and public health strategies.

Purpose of the Study:

  • To identify the predominant rotavirus serotypes causing hospitalizations in Australian children.
  • To analyze the geographical distribution of these serotypes.
  • To inform rotavirus vaccine development and public health interventions.

Main Methods:

  • Analysis of 573 faecal samples from hospitalized children with acute gastroenteritis.
  • Utilized monoclonal antibody immunoassays for serotyping.
  • Employed reverse transcription-polymerase chain reaction (RT-PCR) and polyacrylamide gel electrophoresis (PAGE) for strain characterization.

Main Results:

  • Serotype G9 strains were the most prevalent nationally (74.7%) for the second consecutive year.
  • G9 strains were detected in all seven participating Australian centres.
  • Serotype G1 strains were the second most common (11.3%), found in four centres.

Conclusions:

  • Serotype G9 is the dominant rotavirus strain causing severe gastroenteritis in Australian children.
  • The widespread prevalence of G9 has significant implications for current rotavirus vaccine formulations.
  • Vaccine development strategies may need to consider broader serotype coverage, including G9.

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