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Mast cells in testicular lesions
Sharanamma M Kollur1, V L Pattankar, Imad Abdien El Hag
1Central Laboratories, PARAS Central Hospital, Aljouf, Saudi Arabia. sharanamma@hotmail.com
Upsala Journal of Medical Sciences
|October 29, 2004
Summary
Mast cells, crucial immune cells, show varied distribution in testicular conditions. Their highest concentration is linked to infertility, while lowest is found in testicular tumors, suggesting roles in disease pathogenesis.
Area of Science:
- Urology
- Pathology
- Immunology
Background:
- Mast cells are immune cells implicated in various physiological and pathological processes.
- Their role in testicular pathology, particularly in infertility and neoplasms, is not fully elucidated.
Purpose of the Study:
- To investigate the distribution and density of mast cells in different testicular lesions.
- To compare mast cell counts in normal testes, inflammatory conditions, infertility, and testicular tumors.
Main Methods:
- Histopathological examination of orchidectomized tissue and testicular biopsies.
- Toluidine blue staining of tissue sections.
- Quantification of mast cells per high power field (hpm) in 10 consecutive fields.
Main Results:
- Significant variations in mast cell numbers and distribution were observed across testicular lesions.
- Mast cells were predominantly found in inflammatory infiltrates, granulation tissue, and immature fibrous tissue.
- The highest mast cell concentration (23/hpm) was in infertility, followed by inflammatory/reactive lesions (19/hpm), and the lowest (2/hpm) in testicular neoplasms.
Conclusions:
- Mast cell density differs significantly between infertility, inflammatory lesions, and testicular tumors.
- Infertility exhibits the highest mast cell concentration, whereas testicular tumors show the lowest.
- Further research is warranted to understand the specific roles of mast cells in testicular tumourogenesis and infertility pathogenesis.